Oral Form of semaglutide, a GLP-1 receptor agonist

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AdOral Sema is an orally administered glucagon-like peptide 1 (GLP-1) receptor agonist: semaglutide. Semaglutide is approved as a treatment of type 2 diabetes to improve glycemic control. It is also approved for weight loss and weight maintenance.

Adocia has applied its AdOral® technology to switch the administration route of semaglutide from injectable to oral.

Preclinical results show that AdOral® Sema has a significantly improved absorption.

Preclinical results – Median pharmacokinetic profile of oral semaglutide in dogs over five hours after administration (n=10)

Formulation of semaglutide with AdOral technology demonstrates at least a five-fold higher bioavailability compared to Rybelsus®.

AdOral technology opens up numerous applications for oral formulation of peptides.

AdOral® Sema is available for


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