“Physically glycosylating” proteins to enhance their performance

BioChaperone®: Innovative biopolymers inspired by Heparin

The capacity of heparin, a natural polysaccharide, to form molecular complexes with growth factors was discovered over a decade ago. This physical association through electrostatic interactions improves growth factor activity in three main ways:

• Increasing growth factor solubility
• Protecting the growth factor against enzymatic degradation
• Extending the time of action of the growth factor

 

ADOCIA portfolio: more than 300 patented BioChaperone® molecules

BioChaperone® was “bio-inspired” by heparin with the aim of forming complexes with a large variety of proteins.

ADOCIA developed BioChaperone® in order to mimic the interactive properties of heparin with growth factors, without the anticoagulation properties specific to heparin.

The BioChaperone® platform now includes more than 300 innovative patented polymers, oligomers and small organic compounds. BioChaperone® polymers are for instance dextran-based molecules functionalized with natural amino acid and carboxylate.

BioChaperone® representation

BioChaperone® polymers, oligomers and small organic compounds can interact with proteins of interest to form physical complexes. Those interactions are reversible and do not modify the protein.