“Physically glycosylating” proteins to enhance their performance
BioChaperone®: Innovative biopolymers inspired by Heparin
The capacity of heparin, a natural polysaccharide, to form molecular complexes with growth factors was discovered over a decade ago. This physical association through electrostatic interactions improves growth factor activity in three main ways:
- Increasing growth factor solubility
- Protecting the growth factor against enzymatic degradation
- Extending the time of action of the growth factor
ADOCIA portfolio: more than 300 patented BioChaperone® molecules
BioChaperone® was “bio-inspired” by heparin with the aim of forming complexes with a large variety of proteins.
ADOCIA developed BioChaperone® in order to mimic the interactive properties of heparin with growth factors, without the anticoagulation properties specific to heparin.
The BioChaperone® platform now includes more than 300 innovative patented polymers, oligomers and small organic compounds. BioChaperone® polymers are for instance dextran-based molecules functionalized with natural amino acid and carboxylate.
BioChaperone® polymers, oligomers and small organic compounds can interact with proteins of interest to form physical complexes. Those interactions are reversible and do not modify the protein.