Products: BC PDGF for Chronic Wound Healing

Chronic Ulcers

Chronic wounds are growing in incidence due to the ageing population and the increasing number of diabetics.

Diabetic Foot Ulcer

• 15% of diabetic patients will develop a DFU in their lifetime. DFU is a major and increasing public-health problem. Foot ulcers cause substantial morbidity and are a leading cause of amputations.The number of amputations per year, worldwide, due to diabetes is estimated at over one million. Moreover, diabetic foot ulcer multiplies by 2.4 the risk of death of the patient.
   
• Standard wound care includes cleansing, debridement, pressure relief, moisturizing dressings and infection control. This treatment is often insufficient, resulting in extended healing times and complications such as infections.

Venous leg ulcer

• The leg ulcer is characterized by a chronic skin wound that does not heal spontaneously. Wound has various causes: vascular dysfunction (venous, arterial or mixed), infections, blood disorders, cancer or inflammatory diseases. 80% of cases of leg ulcers are resulting from venous dysfunctions (venous blood reflux, obstruction creating venous stasis *) and are called venous leg ulcer.
   
• Venous leg ulcers are associated with a significant disease burden: pain, difficulty to heal and high recurrence. The current standard treatment consists in compression bandages to improve venous circulation. Alternatives such as skin grafting or cell-based dressings are very expensive and exceptionally used. Surgery to correct the underlying cause of venous insufficiency is the last treatment option. There is a medical need for a cost-effective regenerative treatment based on a growth factor.